Translational research in eating disorders, including biological and psychological factors that contribute to binge eating and purging behaviors; nosology and statistical approaches to classification; epidemiology and cultural factors that influence eating disorders and body image.
Current Research
Current projects include an examination of psychological and biological factors that may distinguish individuals with purging disorder (characterized by recurrent purging following normal or small amounts of food in individuals who are not underweight) from individuals with bulimia nervosa and individuals without eating disorders. We are also using ecological momentary assessment to understand factors that precipitate purging as well as consequences of purging in purging disorder to identify targets for treatment. Finally, several papers are being developed from a large longitudinal and epidemiological study of bulimic syndromes in college cohorts sampled in 1982, 1992, and 2002 that include 10- and 20-year follow-up assessments of the 1992 and 1982 cohorts.
Publications
Selected Publications
Bloss, C. S., Berrettini, W., Bergen, A. W., Magistretti, P., Duvvuri, V., Strober, M., Brandt, H., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C., Kaplan, A. S., Keel, P., Klump, K. L., La Via, M., Mitchell, J., Rotondo, A., Treasure, J., Woodside, D. B., Marzola, E., Schork, N. J., & Kaye, W. H. (in press). Genetic association of recovery from eating disorders: The role of GABA receptor SNPs. Neuropsychopharmacology. PMID: 21750581
Wolfe, B. E., Jimerson, D. C., Smith, A., & Keel, P. K. (2011). Serum amylase in bulimia nervosa and purging disorder: Differentiating the association with binge eating versus purging behavior. Physiology & Behavior, 104, 684-686. PMID: 21781981
Haedt-Matt, A. A., & Keel, P. K. (2011). Revisiting the affect regulation model of binge eating: A meta-analysis of studies using ecological momentary assessment. Psychological Bulletin, 137, 660-681. PMID: 21574678
Keel, P. K., Brown, T. A., Holm-Denoma, J., & Bodell, L. P. (2011). Comparison of DSM-IV versus proposed DSM-5 diagnostic criteria for eating disorders: Reduction of eating disorder not otherwise specified and validity. International Journal of Eating Disorders, 44, 553-560. PMID: 21321984
Keel, P. K., & Heatherton, T. F. (2010). Weight suppression predicts maintenance and onset of bulimic syndromes at 10-year follow-up. Journal of Abnormal Psychology, 119, 268-275. PMID: 20455599
Keel, P. K., Gravener, J. A., Joiner, T. E., & Haedt, A. A. (2010). Twenty-year follow-up of bulimia nervosa and related eating disorders not otherwise specified. International Journal of Eating Disorders, 43, 492-497. PMID: 19718666
Klump, K. L., Keel, P. K., Sisk, C., & Burt, S. A. (2010). Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychological Medicine, 40, 1745-1753. PMID: 20059800.
Keel, P. K., Wolfe, B. E., Liddle, R. A., De Young, K. P., & Jimerson, D. C. (2007). Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. Archives of General Psychiatry, 64, 1058-1066. PMID: 17768271.
Keel, P. K., Baxter, M. G., Heatherton, T. F., & Joiner, T. E. (2007). A 20-year longitudinal study of body weight, dieting, and eating disorder symptoms. Journal of Abnormal Psychology, 116, 422-432. PMID: 17516772.
Wonderlich, S. A., Joiner, T. E., Keel, P. K., Williamson, D. A., & Crosby, R. D. (2007). Eating disorder diagnoses: Empirical approaches to classification. American Psychologist, 62, 167-180. PMID: 17469896.
