Currently, there are two ongoing research programs in my laboratory. The first project investigates the mechanism underlying estradiol's ability to control food intake and regulate body weight in female rodents. To study this problem, we use an integrated approach involving behavioral, physiological, pharmacological, and molecular techniques. The interaction between estrogen and neuropeptides is of particular interest. A second project investigates the changes in neuropeptide secretion associated with activity-based anorexia, an animal model of anorexia nervosa. We are also interested in identifying behavioral patterns in rats that might increase the risk of developing activity-based anorexia.