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Cognitive, Faculty, Neuroscience


Dr. Derek Nee

University of Michigan, 2008

Associate Professor

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Dr. Nee is not recruiting a graduate student for Fall of 2023

Research Interests

Derek Nee uses fMRI and transcranial magnetic stimulation (TMS) to examine the neural mechanisms underlying cognitive control and working memory. In the domain of cognitive control, he seeks to understand how the functional organization of the prefrontal cortex supports the influence of goals and contexts to guide deliberate control over behavior. In the domain of working memory, he explores how the coordination of multiple brain structures underpins the transformation of percepts into thoughts, and the dynamic trajectory those thoughts take in mind. He uses fMRI to reveal the neural correlates of these processes and model interactions between brain regions. This is complemented by TMS to establish the necessity of brain regions to functions to facilitate the creation of mechanistic, causal models of cognition.
He is also interested in the network-wide consequences of TMS including its putative effects on sub-cortical areas such as the hippocampus and ventral striatum. Using a combination of TMS, fMRI, and EEG, he is examining the cognitive and affective impacts of TMS targeting sub-cortical structures.

Selected Publications

Cognitive Control

Nee, D.E. (2021). Integrative frontal-parietal dynamics supporting cognitive control. eLife, 10, e57244.

D’Mello, A.M., Gabrieli, J.D.E., & Nee, D.E. (2020). Evidence for hierarchical cognitive control in the human cerebellum. Current Biology, 30, 1-12.

Nee, D.E. & D’Esposito, M. (2017). Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control. eLife, 6, e28040.

Nee, D.E. & D'Esposito, M. (2016). The hierarchical organization of the lateral prefrontal cortex. eLife, 5, e12112.

Working Memory

Lorenc, E.S., Vandenbroucke, A.R.E., Nee, D.E., de Lange, F.P., & D’Esposito, M. (2020). Dissociable neural mechanisms underlie currently-relevant, future-relevant, and discarded working memory representations. Scientific Reports, 10, 11195.

Lorenc, E.S., Sreenivasan, K., Vandenbroucke, A.R.E., Nee, D.E., & D’Esposito, M. (2018). Flexible coding of visual working memory representations during distraction. Journal of Neuroscience, 38(23), 5267-5276.

Non-invasive stimulation of sub-cortical areas

Ryan, J., Pouliot, J.J., Hajcak, G.*, & Nee, D.E. (in press). Manipulating reward sensitivity using reward circuit-targeted transcranial magnetic stimulation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Tambini, A., Nee, D.E., & D’Esposito, M. (2018). Hippocampal-targeted theta-burst stimulation enhances associative memory formation. Journal of Cognitive Neuroscience, 30(10), 1452-1472.


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