What causes the feelings of hunger and fullness? What makes you decide to stop eating at the end of a meal? Why do so many of us overeat junk food? Why do some people seem naturally thin while others are prone to weight gain and obesity? My laboratory uses rodent models to investigate the diverse factors that control food intake and body weight. Currently, we are focused on how the gut communicates with the brain about nutrients coming into the gastrointestinal tract during meals, and how the brain integrates this information with food palatability, motivation, cues in the environment and learned habits that can promote eating even in the absence of metabolic need.